Fenben lab fenbendazole is an anti-parasitic drug used to treat parasitic infections in animals. It is also a powerful inhibitor of cell growth and has shown promising results in slowing cancer growth in cell culture experiments. However, no randomized clinical trials have tested fenbendazole’s effects on humans with cancer.
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Fenbendazole is a broad-spectrum benzimidazole anthelmintic used to control gastrointestinal parasites in various animal species. It is effective against giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not Dipylidium caninum, the common dog tapeworm), pinworms, aelurostrongylus, and strongyloides. It can be administered to dogs, cats, horses, cattle, sheep, rabbits, fish tanks as planaria and hydra treatments, reptiles, freshwater shrimp tanks, and seals.
It is an important tool in the treatment of helminth infections and has also been used to suppress tumors in human cell cultures. In addition, fenbendazole has been shown to inhibit the growth of some mammalian cancers in experimental animals. It has been proposed that the inhibition of tumor growth by fenbendazole is due to its ability to destabilize microtubules. This mechanism may be related to telomere maintenance and stabilization, which is regulated by telomerase, an enzyme that counteracts the process of cell division.
The repurposing of existing drugs to target unmet medical needs is a key strategy for developing new medicines and reducing the time needed to bring them to market. The anthelmintic fenbendazole is a safe and inexpensive drug that has been extensively tested in numerous animal species. Its wide use in veterinary medicine could make it an excellent candidate for repurposing to target cancer.
We compared the effectiveness of fenbendazole and a vitamin-rich diet in controlling Aspiculuris tetraptera pinworm infestation and human lymphoma xenografts in C.B-17/Icr-Prkdcscid/Crl (SCID) mice, a well-established xenograft model for studying mitochondrial genes in tumorigenesis. A commercial irradiated diet supplemented with either fenbendazole, vitamins, or both was fed to SCID mice with established Aspiculuris tetraptera xenografts. Although all groups of mice exhibited high rates of pinworm control, the fenbendazole-plus-vitamins diet significantly reduced the incidence of tumors in this model. This effect was attributed to the anthelmintic activity of fenbendazole in combination with the high-nutrient diet. Further studies are necessary to determine the precise role of fenbendazole and vitamins in this important mouse model for investigating mitochondrial gene mutations in human lymphoma. These results highlight the importance of evaluating potential human repurposing targets using preclinical models to reduce the time and cost of drug development. The fenbendazole-plus-vitamins group also showed a marked reduction in tumorigenesis in the absence of vitamin E, suggesting that other vitamin cofactors are also required for normal tumor control.